Akathisia, or acathisia, is a syndrome characterized by unpleasant sensations of "inner" restlessness that manifests itself with an inability to sit still or remain motionless (hence the word's origin in Ancient Greek ἁ-, a- "without, not" and κάθισις, káthisis "sitting"). It can be a side effect of medications, mainly neuroleptic antipsychotics especially the phenothiazines (such as perphenazine and chlorpromazine), thioxanthenes (such as flupenthixol and zuclopenthixol) and butyrophenones (such as haloperidol (Haldol)), piperazines (such as ziprasidone), antispasmodics (such as metoclopramide), and usually to a lesser extent antidepressants. Akathisia can also, to a lesser extent, be caused by Parkinson's disease and related syndromes. Antipsychotic psychotropic drugs may cause Parkinsonian like symptoms due to blockage of dopamine receptors in the nigrostriatal pathway of the brain. Another major cause is the withdrawal from opioid medications.Read more on Wikipedia
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