Haemophilia A (also spelled hemophilia A) is the most common form of haemophilia and is also the most common genetic disorder associated with serious bleeding. It is caused by a reduction in the amount or activity of factor VIII. This protein serves as a cofactor for factor IX in the activation of factor X in the coagulation cascade. The lack of this section of the coagulation cascade results in the formation of fibrin deficient clots which makes coagulation much more prolonged, and the clot more unstable.Read more on Wikipedia
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