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Myasthenia Gravis : Pyridostigmine Bromide Vs. Tacrolimus

Definition

Myasthenia gravis (from Greek μύς "muscle", ἀσθένεια "weakness", and Latin gravis "serious"; abbreviated MG) is an autoimmune neuromuscular disease leading to fluctuating muscle weakness and fatiguability. It is an autoimmune disorder, in which weakness is caused by circulating antibodies that block acetylcholine receptors at the post-synaptic neuromuscular junction, inhibiting the stimulative effect of the neurotransmitter acetylcholine. Myasthenia is treated medically with cholinesterase inhibitors or immunosuppressants, and, in selected cases, thymectomy. At 200–400 cases per million it is one of the less common autoimmune disorders . MG must be distinguished from congenital myasthenic syndromes that can present similar symptomatology but offer no response to immunosuppressive interventions.

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