Neuromuscular blocking drugs block neuromuscular transmission at the neuromuscular junction, causing paralysis of the affected skeletal muscles. This is accomplished either by acting presynaptically via the inhibition of acetylcholine (ACh) synthesis or release, or by acting postsynaptically at the acetylcholine receptors of the motor nerve end-plate. While there are drugs that act presynaptically (such as botulinum toxin and tetrodotoxin), the clinically-relevant drugs work postsynaptically.Read more on Wikipedia
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