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Osteitis Deformans : Alendronate Sodium Vs. Zoledronic Acid

Definition

Paget's disease of the bone (other terms are Paget's disease, osteitis deformans, osteodystrophia deformans) is a chronic disorder that typically results in enlarged and deformed bones. The disease is named after Sir James Paget, the British surgeon who first described it in 1877. This paper appeared in the Transactions of the Medical and Surgical Society of London without illustrations; a plate showing his first patient is on display in the pathology museum at St. Bartholomew's Hospital in London. The original article and the illustration have been reunited, together with a modern commentary on Paget's disease, and can be read on-line . The excessive breakdown and formation of bone tissue that occurs with Paget's disease can cause bone to weaken, resulting in bone pain, arthritis, deformities, and fractures.

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