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Ingredients: Estradiol
Average User Review Score
* Based on 26 reviews from across the web.

Hormone replacement therapy (HRT) in menopause is medical treatment in surgically menopausal, perimenopausal and postmenopausal women. Its goal is to mitigate discomfort caused by diminished circulating estrogen and progesterone hormones in menopause. Combination HRT is often recommended as it decreases the amount of endometrial hyperplasia and cancer associated with unopposed estrogen therapy. The main hormones involved are estrogen, progesterone and progestin. Some recent therapies include the use of androgens as well.

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* Extracted from FDA Adverse Event Reports for all drugs with the same active ingredients.

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Druginformer Identified Side Effects: Arthralgia, Abnormal weight gain, Night sweats, Myocardial infarction, Mood swings, Cerebrovascular accident, Blood cholesterol increased

Posted By snapmom in fdb.rxlist.com on February 7, 2014 @ 12:00 am

... The one thing I have noticed is I am gaining weight around my middle, which I didn't have that before. I eat healthy and exercise. I am experiencing more body aches and my joints hurt more. I do tak...

Druginformer Identified Side Effects: Insomnia

Posted By nanou in fdb.rxlist.com on January 2, 2014 @ 12:00 am

I started early premenopause at 39 and had serious symptoms such as heavy night sweats, hot flashes, insomnia and uncontrollable mood swings. I spent 2 years miserable, until my OBGYN prescribed Divi...

Druginformer Identified Side Effects: Acne, Oedema, Tenderness, Vaginal haemorrhage, Weight increased

Posted By Anonymous in askapatient.com on November 6, 2013 @ 12:00 am

... I actually stopped taking it cold turkey and my breasts returned to a more normal state and I am fitting into pants I couldn't before. The problem now is I am experiencing acne breakouts since going o...

Druginformer Identified Side Effects: None

Posted By Anonymous in askapatient.com on April 26, 2013 @ 12:00 am

Side Effects: None I am perimenopausal. Had blood levels tested for all hormones and estrogen level was very low. Adding a small dosage of Divigel really helps. Very easy to apply on a dail...

Druginformer Identified Side Effects: None

Posted By Anonymous in fdb.rxlist.com on February 28, 2013 @ 12:00 am

I'm 68 years old and I have taken Divigel 1mg/dose since about 10 years. It has helped me v.well but after such a long time I tried to stop it with the return of the terrible hot flushes and even a te...

Druginformer Identified Side Effects: None

Posted By Anonymous in fdb.rxlist.com on May 27, 2012 @ 12:00 am

have used twice weekly instead of daily "hot flashes " HAVE SUBSIDED SOMEWHAT

Druginformer Identified Side Effects: Breast tenderness, Rhinitis, Abdominal distension, Vaginal infection, Weight increased

Posted By Divassa in fdb.rxlist.com on November 19, 2011 @ 12:00 am

... Therapy and the side effects of each. Divigel has side effects also and after a week of taking Divigel, I am starting to experience these side effects. A, breast tenderness, B, Sinus inflammation a...

Druginformer Identified Side Effects: Cerebrovascular accident, Sudden death

Posted By colty in fdb.rxlist.com on September 10, 2011 @ 12:00 am

he dr. wants me to start Divigel/Prometrium.I am 65 and I am worried about the side effects. Stroke both my grandparents and my father died from a stroke. Dr. says not to worry but I am. Anybody else...

Druginformer Identified Side Effects: Weight increased, Depressive symptom

Posted By young menopause in fdb.rxlist.com on August 7, 2011 @ 12:00 am

I have been using this medication for 1 year. I was experiencing terrible hot flashes and painful intercourse. The hot flashes subsided within 1 month of use. The painful intercourse remains. I have h...

Druginformer Identified Side Effects: Discomfort, Poor quality sleep

Posted By PJ in fdb.rxlist.com on May 11, 2011 @ 12:00 am

... hormone replacement therapy to a combination of Divigel and Prometrium approximately 6 weeks ago. My hot flashes have increased, disturbing my sleep and making me uncomfortable throughout the day....

* Warning: The facts and figures contained in these reports are accurate to the best of our capability; however, our metrics are only meant to augment your medical knowledge, and should never be used as the sole basis for selecting a new medication. As with any medical decision, be sure to work with your doctor to ensure the best choices are made for your condition.

* About FAERS: The FDA Adverse Event Reporting System (FAERS) is used by FDA for activities such as looking for new safety concerns that might be related to a marketed product, evaluating a manufacturer's compliance to reporting regulations and responding to outside requests for information. Reporting of adverse events is a voluntary process, and not every report is sent to FDA and entered into FAERS. The FAERS database may contain duplicate reports, the report quality is variable, and many factors may influence reporting (e.g., media attention, length of time a drug is marketed, market share). For these reasons, FAERS case reports cannot be used to calculate incidence or estimates of risk for a particular product or compare risks between products.