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Diphenhydramine Hydrochloride

Popular Brands: : Benadryl, Diphenhydramine, Diphenhydramine Hcl, Diphenhydramine Hydrochloride, Allergy Medication
Official FDA Reports220,044
Social Media Events2,575
Total Posts9,107
Avg. Review Score3.49/ 5
Active Ingredients
  • Diphenhydramine Hydrochloride
Brands and Other Names
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Manufacturers
  • 7-eleven
  • A P J Laboratories Limited
  • A-s Medication Solutions Llc
  • Aaa Pharmaceutical, Inc.
  • Aaron Industries, Inc.
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  This report is for all products sharing this active ingredient. For more details, please use our Workbench for research on individual brands like Benadryl.

* Extracted from FDA Adverse Event Report

Explanation

The quarterly trend chart illustrates changing levels of adverse events over time. Results from both the FDA Adverse Event Database (FAERS) and adverse events extracted from social media by Druginformer are plotted side-by-side for easy comparison.


The proportion of people completing user reviews who complained about a side effect.

The proportion of social media adverse event complaints for each adverse event type.

The proportion of FAERS (FDA) adverse event complaints for each adverse event type.


Diphenhydramine Hydrochloride Side Effects

  Social Media
(Online Comments)
FAERS
(Reports Submitted to FDA)
Side Effect On Drug
Label
Overall
Alarm
Reports % of
Reports
Alarm Reports % of
Reports
Alarm

* DrugInformer calculates alarm using a proprietary algorithm. Alarm should not be taken as an ofiicial signal from the FDA or other regulatory entity.


User Voices

The following are comments from users that experienced side effects while taking Diphenhydramine Hydrochloride

Fatigue

bit pricey, tolerance builds quickly works, at first, minimal side effects Works great at first, but tolerance develops quickly Unisom is essentially 'Tylenol PM' without the...


Source: Unisom-Night-Time-Sleep-Aid-Tablets-16...

View full report on Diphenhydramine Hydrochloride related fatigue

Did the author experience fatigue while taking diphenhydramine hydrochloride?

What is this?

Drug Tolerance

bit pricey, tolerance builds quickly works, at first, minimal side effects Works great at first, but tolerance develops quickly Unisom is essentially 'Tylenol PM' without the...


Source: Unisom-Night-Time-Sleep-Aid-Tablets-16...

View full report on Diphenhydramine Hydrochloride related drug tolerance

Did the author experience drug tolerance while taking diphenhydramine hydrochloride?

What is this?

Sluggishness

... essentially 'Tylenol PM' without the Tylenol. I began taking Unisom because I am a chronic insomniac. The side effects have always been very mild for me, mainly just a sluggishness and drowsiness in...


Source: Unisom-Night-Time-Sleep-Aid-Tablets-16...

View full report on Diphenhydramine Hydrochloride related sluggishness

Did the author experience sluggishness while taking diphenhydramine hydrochloride?

What is this?

Tell us about your Experience with Diphenhydramine Hydrochloride

Thank you for sharing your experience with us!

Share Your Experience

Druginformer Identified Side Effects: Mood altered

Posted By Anonymous in fdb.rxlist.com on October 14, 2015 @ 12:00 am

... and just before finishing one of those I read the ingredients. It contains high fructose corn syrup. I avidly avoid high fructose corn syrup in any and all food and drink. So sad to discover it's in Z...

Druginformer Identified Side Effects: Drug dependence, Withdrawal syndrome

Posted By Ccheer in fdb.rxlist.com on October 11, 2015 @ 12:00 am

I take this medicine every night during the week! It helps me tremendously! I used to take Lunesta but I was so addicted to it and would have the worse withdrawals without it and the metallic taste ...

Druginformer Identified Side Effects: Dizziness, General physical health deterioration

Posted By AliceR in fdb.rxlist.com on October 6, 2015 @ 12:00 am

... falling right back to sleep. My only issue is that I still felt somewhat groggy the next morning--I'd say the effects lasted up to 11 hrs. after taking it.But I didn't feel ill or dizzy, just a little...

Druginformer Identified Side Effects: None

Posted By Anonymous in fdb.rxlist.com on September 30, 2015 @ 12:00 am

This seems to help with mild insomnia. However, sometimes I can take 1.5x the directed dose (3 pills instead of 2) and I still can't fall asleep.

Druginformer Identified Side Effects: Abnormal dreams, Psychotic disorder

Posted By Anonymous in fdb.rxlist.com on August 25, 2015 @ 12:00 am

... restroom, I can fall back asleep quickly. Otherwise, my mind wakes up and I can't fall back asleep. It works great for that...the only downside is that it gives me crazy bazaar dreams! where as the t...

Druginformer Identified Side Effects: None

Posted By Anonymous in fdb.rxlist.com on August 13, 2015 @ 12:00 am

It took forever to kick in and I didn't even get a good nights sleep. I kept waking up. I got four hours of sleep and had plenty of time to get more if it had let me.

Druginformer Identified Side Effects: Sleep disorder, Anxiety, Dry mouth, Psychotic disorder

Posted By Anonymous in fdb.rxlist.com on August 12, 2015 @ 12:00 am

made my nerves crazy, dry mouth itchy. no sleep

Druginformer Identified Side Effects: Drug ineffective

Posted By Steph in fdb.rxlist.com on August 4, 2015 @ 12:00 am

Total waste of money and time. Didn't work at all.

Druginformer Identified Side Effects: Pain

Posted By Anonymous in askapatient.com on July 25, 2015 @ 12:00 am

... I have hives and have been taking benadryl for the itching. My doc said it was fine to take as much as needed. I have been taking 8 to 9 a day for 6 weeks and my stomach has been hurting non stop for...

Druginformer Identified Side Effects: Headache, Polyuria, Nausea, Abdominal discomfort, Anxiety, Cardiac flutter, Paraesthesia, Scar

Posted By Anonymous in askapatient.com on July 16, 2015 @ 12:00 am

Side Effects: Head tingling, anxiety, heart racing, face pressure, sick stomach, nausea, head pressure, frequent urination I had an allergic reaction to a bug bite, went to hospital and the...


Additional Drug Information


* Warning: The facts and figures contained in these reports are accurate to the best of our capability; however, our metrics are only meant to augment your medical knowledge, and should never be used as the sole basis for selecting a new medication. As with any medical decision, be sure to work with your doctor to ensure the best choices are made for your condition.

* About FAERS: The FDA Adverse Event Reporting System (FAERS) is used by FDA for activities such as looking for new safety concerns that might be related to a marketed product, evaluating a manufacturer's compliance to reporting regulations and responding to outside requests for information. Reporting of adverse events is a voluntary process, and not every report is sent to FDA and entered into FAERS. The FAERS database may contain duplicate reports, the report quality is variable, and many factors may influence reporting (e.g., media attention, length of time a drug is marketed, market share). For these reasons, FAERS case reports cannot be used to calculate incidence or estimates of risk for a particular product or compare risks between products.