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Popular Brands: : Accutane, Amnesteem, Claravis, Roaccutane, Zenatane
Official FDA Reports103,340
Social Media Events6,107
Total Posts6,117
Avg. Review Score3.78/ 5
Active Ingredients
  • Isotretinoin
Approved Uses *

* Extracted from Drug Label

  • Douglas Pharmaceuticals America Ltd
  • Dr Reddys Laboratories Ltd
  • Hoffmann La Roche Inc
  • Mylan Pharmaceuticals Inc
  • Ranbaxy Inc
Show more manufacturers

  This report is for all products sharing this active ingredient. For more details, please use our Workbench for research on individual brands like Accutane.

* Extracted from FDA Adverse Event Report


The quarterly trend chart illustrates changing levels of adverse events over time. Results from both the FDA Adverse Event Database (FAERS) and adverse events extracted from social media by Druginformer are plotted side-by-side for easy comparison.

The proportion of people completing user reviews who complained about a side effect.

The proportion of social media adverse event complaints for each adverse event type.

The proportion of FAERS (FDA) adverse event complaints for each adverse event type.

Isotretinoin Side Effects

  Social Media
(Online Comments)
(Reports Submitted to FDA)
Side Effect On Drug
Reports % of
Alarm Reports % of

* DrugInformer calculates alarm using a proprietary algorithm. Alarm should not be taken as an ofiicial signal from the FDA or other regulatory entity.

User Voices

The following are comments from users that experienced side effects while taking Isotretinoin


I ended accutane a week ago and I've acquired 4 new pimples since then. Doesn't seem right...

Source: ChasingKelianna/statuses/1944570866403...

View full report on Isotretinoin related acne

Did the author experience acne while taking isotretinoin?

What is this?


Man I have a killer headache . I hate being on Accutane .

Source: xoxoL2/statuses/193867002308329472

View full report on Isotretinoin related headache

Did the author experience headache while taking accutane?

What is this?

Dry Skin

... for Accutane) to be taken twice a day for six months. Yes, I did experience some of the side effects such as headaches (which went away after a couple of weeks) and very dry skin and lips (which was t...

Source: Accutane-Prescription-Acne-Medication-...

View full report on Isotretinoin related dry skin

Did the author experience dry skin while taking isotretinoin?

What is this?

Tell us about your Experience with Isotretinoin

Thank you for sharing your experience with us!

Share Your Experience

Druginformer Identified Side Effects: Arthralgia, Dry skin, Burning sensation, Depression, Dry mouth, Mood altered, Somnolence, Decreased appetite

Posted By Anonymous in askapatient.com on August 15, 2015 @ 12:00 am

Side Effects: Dry skin, cotton mouth, burning forearms, severe joint pain, fatigue, lack of appetite. MOODY!!!! Depression in beginning.

Druginformer Identified Side Effects: None

Posted By Kelly in fdb.rxlist.com on July 13, 2015 @ 12:00 am

My only complaint is that if you are a girl, it's a huge pain to take. You have to prove you are not pregnant and have to take monthly blood tests. It's the program I hate. But the drug? LOVE IT!!!

Druginformer Identified Side Effects: Flatulence, Ageusia, Arthralgia, Back pain, Headache, Pain, Dry skin, Pallor, Myalgia, Hypoaesthesia, Blindness, Tinnitus, Alopecia, Deafness, Abdominal distension, Acne, Diarrhoea, Dry eye, Dry mouth, Hair texture abnormal, Paraesthesia, Photosensitivity reaction, Premature menopause, Somnolence, Onychoclasis, Chemotherapy, Skin sensitisation

Posted By Anonymous in askapatient.com on July 13, 2015 @ 12:00 am

... experienced back pain, ankle pain, dry lips, poor night vision, skin sensitivity to sunlight, and muscle pain in forearms. One month after course ended, experienced bloating, gas, diarrhea, dry eyes, ...

Druginformer Identified Side Effects: Depression, Dry mouth, Scar

Posted By Anonymous in askapatient.com on June 30, 2015 @ 12:00 am

Side Effects: Yes I have clear skin now, with the occasional spot. But I have fell into a deep depression, I feel lost in so many ways I was never a down or deppessed person on the first place even w...

Druginformer Identified Side Effects: Hyperhidrosis, Skin disorder

Posted By jhon in fdb.rxlist.com on June 10, 2015 @ 12:00 am

Dont use it. I have thin fragile skin on forehead and looks like i have hundred pimples when i sweat. I hope dont have to eear a hat for the rest of my life.dont give to your child for god sake.

Druginformer Identified Side Effects: Back pain, Dry skin, Thirst, Dry mouth, Somnolence

Posted By Anonymous in askapatient.com on May 29, 2015 @ 12:00 am

... was a godsend (and cheap!) and so was Dr. Dans Cortibalm (order online). The Cortibalm helped when my lips would swell, Aquaphor kept them from drying out the longest. Back pain, noticed this when dos...

Druginformer Identified Side Effects: Dry skin, Dry mouth, Mood altered

Posted By Anonymous in askapatient.com on May 24, 2015 @ 12:00 am

Side Effects: Very dry lips, dry skin. No negative mood changes, if anything it improved my mood. This drug made me feel amazing when I was on it. I called it my "beauty pill" gave me such ...

Druginformer Identified Side Effects: Arthralgia

Posted By Anonymous in fdb.rxlist.com on May 10, 2015 @ 12:00 am

Personally i loved it. My acne disappeared completely in the third month and i never experienced any side effects like sore joints and muscles even though i was lifting or playing sports every day. Th...

Druginformer Identified Side Effects: None

Posted By Anonymous in fdb.rxlist.com on May 3, 2015 @ 12:00 am

My skin is sooooo dry! hopefully the end result is worth it!

Druginformer Identified Side Effects: Dry mouth

Posted By accutanelover in fdb.rxlist.com on April 29, 2015 @ 12:00 am

Taking accutane has been one of the best decisions of my life. Six months of dry lips was so worth it.

Additional Drug Information

* Warning: The facts and figures contained in these reports are accurate to the best of our capability; however, our metrics are only meant to augment your medical knowledge, and should never be used as the sole basis for selecting a new medication. As with any medical decision, be sure to work with your doctor to ensure the best choices are made for your condition.

* About FAERS: The FDA Adverse Event Reporting System (FAERS) is used by FDA for activities such as looking for new safety concerns that might be related to a marketed product, evaluating a manufacturer's compliance to reporting regulations and responding to outside requests for information. Reporting of adverse events is a voluntary process, and not every report is sent to FDA and entered into FAERS. The FAERS database may contain duplicate reports, the report quality is variable, and many factors may influence reporting (e.g., media attention, length of time a drug is marketed, market share). For these reasons, FAERS case reports cannot be used to calculate incidence or estimates of risk for a particular product or compare risks between products.