DrugInformer Search


Popular Brands: : Arava, Leflunomide
Official FDA Reports80,999
Social Media Events1,969
Total Posts2,772
Avg. Review Score3.17/ 5
Active Ingredients
  • Leflunomide
Brands and Other Names
  • Apotex Inc Etobicoke Site
  • Sanofi Aventis Us Llc

  This report is for all products sharing this active ingredient. For more details, please use our Workbench for research on individual brands like Arava.

* Extracted from FDA Adverse Event Report


The quarterly trend chart illustrates changing levels of adverse events over time. Results from both the FDA Adverse Event Database (FAERS) and adverse events extracted from social media by Druginformer are plotted side-by-side for easy comparison.

The proportion of people completing user reviews who complained about a side effect.

The proportion of social media adverse event complaints for each adverse event type.

The proportion of FAERS (FDA) adverse event complaints for each adverse event type.

Leflunomide Side Effects

  Social Media
(Online Comments)
(Reports Submitted to FDA)
Side Effect On Drug
Reports % of
Alarm Reports % of

* DrugInformer calculates alarm using a proprietary algorithm. Alarm should not be taken as an ofiicial signal from the FDA or other regulatory entity.

User Voices

The following are comments from users that experienced side effects while taking Leflunomide


still having pain

Source: Arava

View full report on Leflunomide related pain

Did the author experience pain while taking arava?

What is this?


Started using Arava when my hair fell out from methotrexate.

Source: Arava

View full report on Leflunomide related alopecia

Did the author experience alopecia while taking arava?

What is this?


I think it's making my fibromylgia worse & it's making me cranky .

Source: Arava

View full report on Leflunomide related irritability

Did the author experience irritability while taking arava?

What is this?

Tell us about your Experience with Leflunomide

Thank you for sharing your experience with us!

Share Your Experience

Druginformer Identified Side Effects: Blood glucose increased

Effectiveness Rating:     Overall Rating:

Posted By Donatella on May 4, 2018 @ 2:23 pm

did anyone have experience with high glucose level - especially if you're diabetic? Only selected once star because it's too early to comme

Druginformer Identified Side Effects: Fatigue, Abnormal weight gain, Diarrhoea, Decreased appetite

Posted By Garyb in fdb.rxlist.com on October 13, 2015 @ 12:00 am

I started Arava 4 months ago to augment Mothotrexate. I have lost almost 10 lbs and am always tired. I am not eating less and don't have enough energy to exercise so I should be gaining weight but I h...

Druginformer Identified Side Effects: Feeling cold, Pruritus, Diarrhoea, Discomfort, Rash, Decreased appetite

Posted By Anonymous in askapatient.com on September 18, 2015 @ 12:00 am

... mild, sometimes severe. The other 2/3 of the time no problems. No hair loss. Mild appetite suppression. No itching. No rash. Labs are normal so far. I have a nasty cold right now that doesn't seem...

Druginformer Identified Side Effects: Diarrhoea

Posted By Anonymous in askapatient.com on September 15, 2015 @ 12:00 am

Side Effects: Some mild diarrhea I was in so much pain prior. Uric acid and inflammation levels off the scale. Was taking Tramadol 3x day as I had prior kidney cancer and cannot take NSAIDs...

Druginformer Identified Side Effects: Chest pain, Nausea, Alopecia

Posted By Anonymous in askapatient.com on August 26, 2015 @ 12:00 am

Side Effects: Nausea, chest pain, considerable hair loss Arava did help with the RA pain and inflammation but the side effects were not worth it. Going through the washout now and hoping t...

Druginformer Identified Side Effects: None

Posted By Anonymous in askapatient.com on August 17, 2015 @ 12:00 am

Side Effects: I have been on this drug for a week do you get side affects straight away or can it take a few weeks to kick in .. ive heard it can take a good few weeks before you can get any side aff...

Druginformer Identified Side Effects: Alopecia, Vision blurred

Posted By Linda in fdb.rxlist.com on August 6, 2015 @ 12:00 am

... but no improvement, in fact still progressing, in lungs. Now considering lung biopsy and possibility of transplant. Only side effects I've notice with Arava is slight hair thinning and some blurred ...

Druginformer Identified Side Effects: Pain, Pruritus, Alopecia, Diarrhoea, Photosensitivity reaction, Menstruation irregular

Posted By Anonymous in askapatient.com on July 25, 2015 @ 12:00 am

Side Effects: Horrible sun sensitivity. To the point my skin hurt after mowing and ended up with little red raised itchy spots all over. I never put 2 and 2 together, but I have also had the diarrhea...

Druginformer Identified Side Effects: Ageusia, Diarrhoea

Posted By Anonymous in askapatient.com on July 13, 2015 @ 12:00 am

Side Effects: Loss of taste and smell diarehha but didn't start until about 6 weeks after starting medication

Druginformer Identified Side Effects: Diarrhoea, Rash

Posted By Anonymous in askapatient.com on May 29, 2015 @ 12:00 am

Side Effects: When I mentioned to my rheumatologist about the annoying diarrhea, she immediately said, "Oh! That's dosage related! We can fix that!" She dropped me from 20 mg. to 10 mg. and I hav...

Additional Drug Information

* Warning: The facts and figures contained in these reports are accurate to the best of our capability; however, our metrics are only meant to augment your medical knowledge, and should never be used as the sole basis for selecting a new medication. As with any medical decision, be sure to work with your doctor to ensure the best choices are made for your condition.

* About FAERS: The FDA Adverse Event Reporting System (FAERS) is used by FDA for activities such as looking for new safety concerns that might be related to a marketed product, evaluating a manufacturer's compliance to reporting regulations and responding to outside requests for information. Reporting of adverse events is a voluntary process, and not every report is sent to FDA and entered into FAERS. The FAERS database may contain duplicate reports, the report quality is variable, and many factors may influence reporting (e.g., media attention, length of time a drug is marketed, market share). For these reasons, FAERS case reports cannot be used to calculate incidence or estimates of risk for a particular product or compare risks between products.