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Bupropion Hydrochloride Related Discomfort

Official FDA Reports126
Social Media Events218
Active Ingredients
  • Bupropion Hydrochloride
Additional Terms for Discomfort
  • Uncomfortable
  • Ill
  • All Over Pain
  • Ucky Feeling
  • Not Feeling Well
Show more

  This report is for all products sharing this active ingredient. For more details, please use our Workbench for research on individual brands like Wellbutrin.


The quarterly trend chart illustrates changing levels of adverse events over time. Results from both the FDA Adverse Event Database (AERS) and adverse events extracted from social media by Druginformer are plotted side-by-side for easy comparison.

List of Possible Side Effects Reported

Report Date Dosage Indication Outcome Country Gender Age Weight (lbs)

* DrugInformer calculates alarm using a proprietary algorithm. Alarm should not be taken as an ofiicial signal from the FDA or other regulatory entity.

Social Media Comments From Around the Web

The following are comments from users that experienced side effects while taking Milnacipran Hydrochloride


Used briefly, felt horrible on it.

Source:" Wellbutrin

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Did the author experience discomfort while taking wellbutrin?

What is this?


Helps my depression the best but has been less effective lately. Course my depression wouldnt be so bad if I wasnt sick all the time.

Source:" Wellbutrin

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Did the author experience discomfort while taking wellbutrin?

What is this?


Just started and having some uncomfortable effects.

Source:" Wellbutrin

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Did the author experience discomfort while taking wellbutrin?

What is this?

Tell us about your Experience with Bupropion Hydrochloride Related Discomfort

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Druginformer Identified Side Effects: Urinary incontinence, Arthralgia, Irritability, Fatigue, Insomnia, Eye allergy, Impatience, Discomfort, Nightmare

Effectiveness Rating:     Overall Rating:

Posted By Ellie on July 7, 2016 @ 6:12 pm

The side effect list pretty much says it all. The only one that I want to clarify is eye allergies. It just feels like allergies with the stinging and irritation. All of them either started or were worsened, like my arthritis, when I started this drug and worsened when my dose was increased. I'm still decreasing dosage to stop taking it, and the effects haven't gone away yet, but haven't gotten worse. I really hope it all goes away.

Druginformer Identified Side Effects: Abdominal pain, Agitation, Vomiting, Urticaria, Aggression, Discomfort

Posted By Anonymous in askapatient.com on April 25, 2015 @ 12:00 am

Side Effects: Good God! One night of hell! I didn't read the side effects first. My stomach hurt soooo bad, and yes I had food with it. I got hives all over my arm, the side from breast cancer ly...

Druginformer Identified Side Effects: Malaise, Nausea, Paranoia, Adverse event, Food craving, Increased appetite, Dehydration, Discomfort, Dry mouth, Hyperhidrosis, Influenza like illness, Weight decreased, Musculoskeletal discomfort, Product taste abnormal

Posted By Anonymous in askapatient.com on January 11, 2015 @ 12:00 am

... of 3-4 years. I also took it in mid 20's but only vaguely recall nausea, dry mouth, and sweats. Recently increas my dose from 150-300mg and I feel terrible. So this is why I feel sick all the time? I...

Druginformer Identified Side Effects: Tremor, Tinnitus, Discomfort, Grand mal convulsion, Weight decreased

Posted By katred in fdb.rxlist.com on August 22, 2014 @ 12:00 am

... office staff be educated on signs of impending seizure. I called the doctor's office to report very uncomfortable side effects that seemed to come on rather quickly (tremor, severe ringing in the...

Druginformer Identified Side Effects: Night sweats, Erectile dysfunction, Thought withdrawal, Discomfort, Withdrawal syndrome

Posted By Anonymous in askapatient.com on April 16, 2014 @ 12:00 am

Side Effects: Missing 1 dosage can lead to uncomfortable withdrawal effects (called "brain shivers). Causes a mild case of erectile dysfunction. Causes night sweats. Took Effexor XR for a...

Druginformer Identified Side Effects: Nausea, Anxiety, Discomfort, Insomnia, Loss of libido, Appetite disorder

Posted By berlinATX in fdb.rxlist.com on January 23, 2014 @ 12:00 am

... person and have lost all creative emotion. Enter Wellbutrin again. First day I've got pupils so dilated I can hardly function, massive anxiety, can't sleep, can't eat, nausea, everything smells strong...

Druginformer Identified Side Effects: Discomfort

Posted By cheryls in fdb.rxlist.com on November 9, 2013 @ 12:00 am

I would like to know if anyone has went off of this drug and had any withdrawals from it. with all of the ill effects of meds I don't know if there worth taking.

Druginformer Identified Side Effects: Headache, Dizziness, Lactose intolerance, Discomfort, Decreased appetite, Appetite disorder

Posted By armani13 in fdb.rxlist.com on October 18, 2013 @ 12:00 am

... side effects, I am lactose intolerant and have IBS so any nausea or other discomfort have been indistinguishable. I have occasionally experienced dizziness and slight headaches but other than that, I...

Druginformer Identified Side Effects: Headache, Apathy, Discomfort, Drug ineffective, Insomnia

Posted By Anonymous in askapatient.com on April 8, 2013 @ 12:00 am

Side Effects: Side effects: slight headache for first 2 or 3 days. Other than that nothing else as of yet. This medication is truly wonderful! I used to be such an energetic person, but last year I h...

Druginformer Identified Side Effects: Weight increased, Discomfort, Suicidal ideation, Withdrawal syndrome, Emotional distress, Psychotic disorder

Posted By Anonymous in askapatient.com on February 14, 2013 @ 12:00 am

Side Effects: Weight gain. Reduced mental clarity. Heightened emotions. Suicidal thoughts. Withdrawal is a btch. I was on 225 mg for a long time and then tapered down to 37.5 mg. Reason I'm writing t...

* Warning: The facts and figures contained in these reports are accurate to the best of our capability; however, our metrics are only meant to augment your medical knowledge, and should never be used as the sole basis for selecting a new medication. As with any medical decision, be sure to work with your doctor to ensure the best choices are made for your condition.

* About FAERS: The FDA Adverse Event Reporting System (FAERS) is used by FDA for activities such as looking for new safety concerns that might be related to a marketed product, evaluating a manufacturer's compliance to reporting regulations and responding to outside requests for information. Reporting of adverse events is a voluntary process, and not every report is sent to FDA and entered into FAERS. The FAERS database may contain duplicate reports, the report quality is variable, and many factors may influence reporting (e.g., media attention, length of time a drug is marketed, market share). For these reasons, FAERS case reports cannot be used to calculate incidence or estimates of risk for a particular product or compare risks between products.